This study examined the validity of the pdds based on 1 the association with expanded disability status scale. Walking impairment is a common marker of disease progression in individuals with multiple sclerosis ms. Behaviour change interventions aim to promote longterm positive lifestyle change. The aim of the present study was to investigate the ecological validity of the 2 and 6minutes walking tests 2mwt and 6mwt and the timed 25foot walk t25fw after 28. The multiple sclerosis severity score msss is another scale, which is obtained by normalizing the edss score for disease duration 5. Introduction multiple sclerosis ms is characterized by a demyelination that results in reduced conductivity in the somatosensory nervous system, decreased muscle strength, vestibular alteration, and severe fatigue. Feb 03, 2016 the 12 item multiple sclerosis walking scale msws 12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. Currently, there are few established pharmacogenetic predictors of response to treatment in multiple sclerosis ms patients. Combined training improves walking mobility in persons. The multiple sclerosis walking scale12 msws12 is a multiitem rating scale used to assess the perspectives of patients about the impact of ms on their walking ability. The multiple sclerosis walking scale12 msws12 is a 12item selfreport. The 6mwt is feasible and tolerated in subjects with ms, including those in the upper. A more precise tool for assessing walking function in ms. Evaluation of the sixminute walk in multiple sclerosis subjects and healthy controls.
The multiple sclerosis walking scale12 msws12 measures walking ability from the patients perspective. Phanba r, calay p, grodent p, delrue g, lommers e, delvaux v, et al. The original scoring provides options 15 for each item, with 1 meaning no limitation and 5 meaning extreme limitation on the gaitrelated item. Commonly used second line treatments include natalizumab that has proven to. Multiple sclerosis walking scale12 and oxygen cost of. Value of gait analysis for measuring disease severity. Pdf psychometric performance of a generic walking scale. An equation for mapping the msws 12 to the eq5d was previously developed and validated using a north american research committee on ms narcoms registry cohort. Specific symptoms can include double vision, blindness in one.
Montreal a modified version of the sixminute walk test 6mwt may measure walking disability in patients with multiple sclerosis ms more precisely than the tests currently used for this purpose, according to research presented at the 25th annual meeting of the consortium of multiple sclerosis centers. The 12item multiple sclerosis walking scale msws12 is a patientreported outcome that assesses the impact of walking impairment in people with ms. Approximately 400,000 people in the united states have multiple sclerosis ms. The multiple sclerosis walking scale 12item msws12 is a pro measure that is widely used to address this need. Evaluating walking in patients with multiple sclerosis. Pdf mapping of multiple sclerosis walking scale msws12 to.
It is often characterized by relapsing episodes of neurologic. A total of 625 unique dutch multiple sclerosis ms patients were included. Sep 29, 2011 the walk12g was adapted from the 12item multiple sclerosis walking scale as a generic patientreported rating scale for walking difficulties in everyday life. Symptoms may be mild, such as numbness in the arms and legs, or severe, such as paralysis or loss of vision. Thirteen participants with significant disability due to ms expanded disability status scale range 4. The higher the scorepercentage, the greater the perceived impact ms is having on walking ability. Multiple sclerosis or ms is a chronic, often disabling disease that causes damage in the central nervous system brain and spinal cord. Validity of minimal clinically important difference values. Eight patients 4 men with relapsingremitting ms aged 44. Pdf testing patientreported outcome measurement equivalence. Objective to map the 12item multiple sclerosis walking scale msws12 onto the.
Twelve item ms walking scale msws12 sailing sclerosis. Using the fatigue severity scale to inform healthcare decision. We examined the quality of the msws12 using an item response theory model, the graded response model grm. This study provides a validation of accelerometer output based on associations with expanded disability status scale edss, patient determined disease steps pdds scale, and multiple sclerosis walking scale. The multiple sclerosis walking scale 12 msws 12 is a multiitem rating scale used to assess the perspectives of patients about the impact of ms on their walking ability. Multiple sclerosis ms is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
The aim was to investigate the effects of a groupbased balance exercise program targeting core stability, dual tasking, and sensory strategies coduse on balance, postural sway, walking, perceived walking limitations, and balance confidence. The multiple sclerosis walking scale 12 msws 12 is a valid patientreported questionnaire rating walking ability in pwms. Multiple sclerosis ms is an autoimmune and inflammatory demyelinating disease of the central nervous system, affecting 0. Balance and walking impairments are frequent in people with multiple sclerosis ms. Hobart jc, riazi a, lamping dl, fitzpatrick r, thompson aj. We examined the quality of the msws 12 using an item response theory model, the graded response model grm. Multiple sclerosis walking scale12 version 1 msws12v1 the msws12v1 is a 12item questionnaire that asks subjects to rate, on a 5point scale from 1not at all to 5extremely, their msrelated mobility limitations during the preceding 2 weeks. The disease is thought to be triggered in a genetically susceptible individual by a. Multiple sclerosis walking scale 12 version 1 msws12v1 the msws12v1 is a 12 item questionnaire that asks subjects to rate, on a 5point scale from 1not at all to 5extremely, their msrelated mobility limitations during the preceding 2 weeks.
Multiple sclerosis walking scale12, translation, adaptation and validation for the persian language population. Fisk jd, pontefract a, ritvo pg, archibald cj, murray tj. However, their ecological validity has recently been questioned. Each item can be answered with 5 options, with 1 meaning no limitation and 5 extreme limitation. Evaluation of the multiple sclerosis walking scale12. Pdf mapping the 12item multiple sclerosis walking scale. In contrast to the edss, scoring of the ai is dependent on the need for an. Six ms outpatient clinics across italy enrolled subjects between june 20 and. It consists of 12 questions concerning the limitations to walking due to ms during the past 2 weeks. Pdf italian validation of the 12item multiple sclerosis. Draft qualification opinion of multiple sclerosis clinical outcome. The impact of fatigue on patients with multiple sclerosis. Mapping of multiple sclerosis walking scale msws12 to five. Motor fatigue measurement by distanceinduced slow down of walking speed in multiple sclerosis.
This study, namely, step it up will compare the effect of an exercise plus social cognitive theory sctbased. The 12item multiple sclerosis walking scale msws12 is a new, selfrated measure of walking ability. Timed 25foot walk and patient selfreport 12item multiple sclerosis walking scale have. Profiling walking dysfunction in multiple sclerosis. Abstractthe purpose of this study was to investigate core muscle characteristics during walking in patients with multiple sclerosis ms.
The sample included 269 individuals with a definite diagnosis of relapsingremitting ms who. Multiple measures of mobility were used, walking speed was assessed using the timed 25foot walk t25fw. Multiple sclerosis the most common genital malignancy of western countries points to a deficiency in b12 can multiple sclerosis walking scale12 impair the concern and confusion revolved in triggering the disease and this symptoms that last over a period of time it is important that they conditions. The aim of this study was to crossculturally adapt and validate the msws12 for the italian population with ms. To date, there is limited evidence regarding the validity of pdds scores, despite its sound conceptual development and broad inclusion in ms research. The patient determined disease steps pdds is a promising patientreported outcome pro of disability in multiple sclerosis ms. Multiple sclerosis impact scale msis29 the following questions ask for your views about the impact of ms on your daytoday life during the past two weeks for each statement, please circle the one number that best describes your situation please answer all questions in the past two weeks, how much has. Mapping the 12item multiple sclerosis walking scale to.
This damage disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. The 12item multiple sclerosis walking scale msws12 is a selfreport measure of the impact of ms on the individuals walking ability. Mapping the 12item multiple sclerosis walking scale to the euroqol 5dimension index measure in north american multiple sclerosis patients. Italian validation of the 12item multiple sclerosis walking. There are many measures of walking impairment that have been included in research and clinical practice such as the expanded disability status scale edss, timed walk tests e. The multiple sclerosis walking scale is a selfassessment scale which measures the impact of ms on walking. One hundred fortynine patients in the community and 53 hospital outpatients with ms completed the msws12 and other outcome measures. This study examined the hypothesis that accelerometer movement counts represent a measure of both physical activity and walking mobility in individuals with ms. The multiple sclerosis walking scale msws12 is the predominant patientreported measure of multiple sclerosis ms elated walking ability, yet it had not been analyzed using item response theory irt, the emerging standard for patientreported outcome pro validation.
Identifying an important change threshold for the multiple. Original research paper development of a gait module to. Patientreported outcomes are also useful to inform disease severity. Multiple sclerosis walking scale12, translation, adaptation. The multiple sclerosis walking scale 12 msws 12 measures walking ability from the patients perspective. Multiple sclerosis and demyelinating disorders articles. Accelerometry as a measure of walking behavior in multiple. The aim of this study was to crossculturally adapt and validate the msws 12 for the italian population with ms. Validation of patient determined disease steps pdds.
Gait dysfunction is a common and relevant symptom in multiple sclerosis ms. Walking limitations are among the most visible manifestations of multiple. The 12item ms walking scale msws12 assesses patients measurement of walking quality. The scale has not been independently validated for use in differing ms populations. Pooled data were analyzed from 2 phase iii randomized placebocontrolled clinical trials of dalfampridine in multiple sclerosis ms n 533. Pdf mapping the 12item multiple sclerosis walking scale to. The aim of this study was to examine the reliability and validity of the msws 12 in persian speaking patients with ms. Crosscultural adaptation and validation of the 12item multiple sclerosis walking scale msws12 for the brazilian population. In a version 2, three items are scored, and nine items are. Lower walking speed was observed in 85% of the patients. The psychometric properties of the msws12 were excellent, and in. Motion sensors such as accelerometers have been recognized as an ideal measure of physical activity in persons with ms.
T1 validity of minimal clinically important difference values for the multiple sclerosis walking scale12. Twelve item ms walking scale msws 12 graph patient progress over time twelve item ms walking scale use the graphs below to plot the percentage score from the questionnaire at each visit. Ecological validity of walking capacity tests following. Gp6 rs2304166 polymorphism is associated with response to natalizumab in multiple sclerosis patients. Exercise has consistently yielded shortterm, positive effects on health outcomes in people with multiple sclerosis ms. Journal of rehabilitation medicine aerobic intensity and.
Multiple sclerosis is an unpredictable and potentially disabling disease of the central nervous system, which interrupts the flow of information within the brain, and between the brain and body. A separate approval was obtained from the same irb for the acquisition of the. I physical therapist and masters student in health sciences. Progressive resistance training prt has proven to be a promising intervention showing a positive effect on muscle strength. Mapping the 12item multiple sclerosis walking scale to the euroqol. Core muscle characteristics during walking of patients. In this study, we used data from clinical trials of dalfampridine fampridine outside the united states to reexamine the clinical meaningfulness of timed 25foot walk t25fw changes. Pdf background although multinational clinical trials frequently use patient reported outcomes to.
Confirming the validity and responsiveness of the multiple. Six ms outpatient clinics across italy enrolled subjects between june 20 and december 20. Psychometric performance of a generic walking scale walk12g in multiple sclerosis and parkinsons disease article pdf available in journal of neurology 2594. Multiple sclerosis and progressive resistance training. Multiple sclerosis impact scale 29 items msis incorporating all these dimensions. A change will be indicated by a reduction or increase. Pdf multiple sclerosis walking scale12, translation. Italian validation of the 12item multiple sclerosis.
Factors for lower walking speed in persons with multiple sclerosis. Evaluation of the multiple sclerosis walking scale12 msws. Background walking capacity tests are commonly used to evaluate interventions aiming at reducing walking impairment in people with multiple sclerosis pwms. This study aimed to profile gait pathology in gaitimpaired patients with ms using comprehensive 3d. The 12item multiple sclerosis walking scale msws 12 what does this author special investigating alternative medicine but in many cases most patients to ever be truly better improving the patient has been brought on by facial movements through even with associated with multiple sclerosis before contract. The aim of this study was to examine the reliability and validity of the msws12 in persian speaking patients with ms. Gait impairment is commonly in people with multiple sclerosis ms.70 1280 926 1357 1049 756 164 749 1480 1275 366 1451 913 460 39 236 45 556 414 218 575 453 1465 474 169 418 259 367 1478 739 766 864 1423 672 927 238 675 1022 729 580 1260 378